Intimate hyperpigmentation is caused by an excess of melanin formation around the anal and
external genital area which causes darkening of the skin.
What causes hyperpigmentation in the intimate area?
Hyperpigmentation is a disorder of multifactorial origin and the triggering factors include:
- Age: aging of the vaginal tissue is caused by changes in the biological, biochemical and molecular mechanisms that can result in pigmentation disorders.
- Genetic predisposition: the prevalence is higher in persons with high phototypes (IV, V and VI).
- Hormonal changes: the increase of oestrogens stimulates the activity of the enzyme tyrosinase responsible for the increased melanin production.
- Care and beauty habits: techniques such as depilation can cause abrasion and folliculitis, leading to skin inflammation that results in an increased production of the melanocytes and therefore of melanin.
- Clothing habits: when the skin experiences friction, it naturally thickens (hyperkeratinisation) and darker areas appear. It often affects the inner thighs in case of frequent use of tight pants or underwear.
- dermamelan® intimate, acts:
- in all phases of the melanogenesis process to remove the existing hyperpigmentation and prevent its recurrence (both a corrective and regulating action).
- on the inflammatory process, blocking cyclo-oxygenase (COX), an enzyme responsible for theformation of inflammatory mediators such as prostaglandins (PG).
- stimulating the renewal of the outermost skin layers, and stimulating the production of fibroblasts, responsible for the formation of collagen and elastin.
- removes the melanin deposits built-up in the horny layer.
- reduces the amount of melanin formed, thus decreasing the intensity of pigmentation.
- blocks the transfer of melanosome from the melanocytes to the keratinocytes.
- Reduces the activation of tyrosinase, as it contains Cu2+ chelating active ingredients
- Reduces the oxidising reactions of tyrosine, neutralising ROS.
- Inhibits the enzyme tyrosinase neutralising its action.